Systematic expression analysis of ligand-receptor pairs reveals important cell-to-cell interactions inside glioma

Systematic expression analysis of ligand-receptor pairs reveals important cell-to-cell interactions inside glioma

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Abstract Background Glioma is the most commonly diagnosed malignant and aggressive brain cancer in adults.Traditional researches mainly explored the expression profile of glioma at cell-population level, but ignored the heterogeneity and interactions of among glioma cells.Methods Here, we firstly analyzed the single-cell RNA-seq (scRNA-seq) data of 6341 glioma cells using manifold learning and identified neoplastic and healthy cells infiltrating in tumor microenvironment.

We systematically revealed cell-to-cell guest check pad holder interactions inside gliomas based on corresponding scRNA-seq and TCGA RNA-seq data.Results A total of 16 significantly correlated autocrine ligand-receptor signal pairs inside neoplastic cells were identified based on the scRNA-seq and TCGA data of glioma.Furthermore, we explored the intercellular communications between cancer stem-like cells (CSCs) and macrophages, and identified 66 ligand-receptor pairs, some of which could significantly affect prognostic outcomes.

An efficient machine learning model was constructed to accurately predict jumbo glory double wall 2li bardak 250 ml the prognosis of glioma patients based on the ligand-receptor interactions.Conclusion Collectively, our study not only reveals functionally important cell-to-cell interactions inside glioma, but also detects potentially prognostic markers for predicting the survival of glioma patients.